ABSTRACT
Objective To investigate the clinical and CT features of non-epithelial malignant tumors of bladder to improve the understanding.Methods Clinical and CT data of 1 1 patients with non-epithelial malignant tumors of bladder were analyzed retrospectively. All patients underwent plain and contrast enhanced CT scan,and confirmed by surgery and pathology.Results Of 1 1 patients,there were 4 rhabdomyosarcomas,3 cancerous sarcomas,2 leiomyosarcomas and 2 small cell carcinomas.The CT performance were mostly cauliflower like or papillary,with wide basis and thickening of adjacent bladder wall.Diffuse thickening of the bladder wall was detected in all rhabdomyosarcoma lesions.The lesions were homogeneous or heterogeneous soft tissue-like density.CT showed calcification in 1 cancerous sarcoma,necrosis in 1 leiomyosarcoma and 1 rhabdomyosarcoma.Contrast enhanced scan showed mild to moderate or significant enhancement.Conclusion Besides the age of rhabdomyosarcoma,other non-epithelial malignant tumors of bladder have no special clinical and CT characteristics.CT examination can provide the information about location,size,surrounding tissue change,which is helpful to make the treatment plan.
ABSTRACT
OBJECTIVE@#To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method.@*METHOD@#With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinical pathological factor.@*RESULT@#Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship.@*CONCLUSION@#Active Stat3 may promote the transcription of target gene Cyclin D1, which could accelerate carcinomatous change.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Carcinoma, Squamous Cell , Metabolism , Pathology , Cyclin D1 , Metabolism , Immunohistochemistry , Laryngeal Neoplasms , Metabolism , Pathology , Neoplasm Staging , STAT3 Transcription Factor , MetabolismABSTRACT
Objective:To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method.Method:With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinical pathological factor.Result:Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship.Conclusion:Active Stat3 may promote the transcription of target gene Cyclin D1,which could accelerate carcinomatous change.
ABSTRACT
Problem-based Learning(PBL)in medical education is the method of instruction using problems of clinical medicine to stimulate students' driving force of learning and guide them to grasp the learning contents.Compared with the traditional teaching method,it has the fundamental difference in the designing idea,implementing mode,evaluation system and actual effect.The management of PBL teaching process and the active creation of teaching environment and conditions are the key factors to ensure the successful implementation of PBL.